diff --git a/compiler/rustc_trait_selection/src/traits/select/mod.rs b/compiler/rustc_trait_selection/src/traits/select/mod.rs
index 8adf9015933..27acb87d221 100644
--- a/compiler/rustc_trait_selection/src/traits/select/mod.rs
+++ b/compiler/rustc_trait_selection/src/traits/select/mod.rs
@@ -982,6 +982,14 @@ impl<'cx, 'tcx> SelectionContext<'cx, 'tcx> {
         param_env: ty::ParamEnv<'tcx>,
         trait_ref: ty::ConstnessAnd<ty::PolyTraitRef<'tcx>>,
     ) -> Option<EvaluationResult> {
+        // Neither the global nor local cache is aware of intercrate
+        // mode, so don't do any caching. In particular, we might
+        // re-use the same `InferCtxt` with both an intercrate
+        // and non-intercrate `SelectionContext`
+        if self.intercrate {
+            return None;
+        }
+
         let tcx = self.tcx();
         if self.can_use_global_caches(param_env) {
             if let Some(res) = tcx.evaluation_cache.get(&param_env.and(trait_ref), tcx) {
@@ -1004,6 +1012,14 @@ impl<'cx, 'tcx> SelectionContext<'cx, 'tcx> {
             return;
         }
 
+        // Neither the global nor local cache is aware of intercrate
+        // mode, so don't do any caching. In particular, we might
+        // re-use the same `InferCtxt` with both an intercrate
+        // and non-intercrate `SelectionContext`
+        if self.intercrate {
+            return;
+        }
+
         if self.can_use_global_caches(param_env) {
             if !trait_ref.needs_infer() {
                 debug!(?trait_ref, ?result, "insert_evaluation_cache global");